Tab amlodipine 2.5mg
High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Amlodipine is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely. Tell your doctor about all other heart or blood pressure medications you are taking. Your chest pain may become worse when you first start taking amlodipine or when your dose is increased.
Call your doctor if your chest pain is severe or ongoing. Before taking this medicine You should not take amlodipine if you are allergic to it.
To make sure amlodipine is safe for you, tell your doctor if you have: It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Amlodipine can pass into breast milk, but effects on the nursing baby are not known.
Tell your doctor if you are breast-feeding. Amlodipine is not approved for use by anyone younger than 6 years old. How should I take amlodipine?
Take amlodipine exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Amlodipine has been shown to prolong both the gestation period and the duration of labor in rats at this dose [see Data ]. The estimated background risk of major birth defects and miscarriage for the indicated population is unknown.
All pregnancies have a background risk of birth defect, loss or other adverse outcomes. Hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death. Pregnant women with hypertension should be carefully monitored and managed accordingly. Amlodipine maleate has been shown to prolong both the gestation period and the duration of labor in rats at this dose. No adverse effects of amlodipine on the breastfed infant have been observed. There is no available information on the effects of amlodipine on milk production.
Effect of amlodipine besylate tablets on blood pressure in patients less than 6 years of age is not known. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
In humans, experience with intentional overdosage of amlodipine besylate tablets is limited. If massive overdose should occur, initiate active cardiac and respiratory monitoring. Frequent blood pressure measurements are essential.
Should hypotension occur, provide cardiovascular support including elevation of the extremities and the judicious administration of fluids. If hypotension remains unresponsive to these conservative measures, consider administration of vasopressors such as phenylephrine with attention to circulating volume and urine output.
As amlodipine besylate tablets are highly protein bound, hemodialysis is not likely to be of benefit. Amlodipine besylate, USP is a white or almost white powder with a molecular weight of It is slightly soluble in water and sparingly soluble in ethanol. All pregnancies have a background risk of birth defect, loss or other adverse outcomes. Hypertension increases the fetal risk for intrauterine growth restriction and intrauterine death.
Pregnant women with hypertension should be carefully monitored and managed accordingly. Amlodipine maleate has been shown to prolong both the gestation period and the duration of labor in rats at this dose. Lactation Risk Summary Limited available data from a published clinical lactation study reports that Amlodipine is present in human milk at an estimated median relative infant dose of 4.
No adverse effects of Amlodipine on the breastfed infant have been observed. There is no available information on the effects of Amlodipine on milk production. Pediatric Use Amlodipine besylate 2. Effect of Amlodipine besylate on blood pressure in patients less than 6 years of age is not known.
Geriatric Use Clinical studies of Amlodipine besylate did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.
Overdosage Overdosage might be expected to cause excessive peripheral vasodilation with marked hypotension and possibly a reflex tachycardia. In humans, experience with intentional overdosage of Amlodipine besylate is limited. If massive overdose should occur, initiate active cardiac and respiratory monitoring. Frequent blood pressure measurements are essential. Should hypotension occur, provide cardiovascular support including elevation of the extremities and the judicious administration of fluids.
If hypotension remains unresponsive to these conservative measures, consider administration of vasopressors such as phenylephrine with attention to circulating volume and urine output. As Amlodipine besylate is highly protein bound, hemodialysis is not likely to be of benefit. Amlodipine Description Amlodipine besylate is the besylate salt of Amlodipine, a long-acting calcium channel blocker.
Amlodipine besylate is a white crystalline powder with a molecular weight of It is slightly soluble in water and sparingly soluble in ethanol. Amlodipine besylate tablets, USP are formulated as white tablets equivalent to 2. In addition to the active ingredient, Amlodipine besylate, each tablet contains the following inactive ingredients: Amlodipine - Clinical Pharmacology Mechanism of Action Amlodipine is a dihydropyridine calcium antagonist calcium ion antagonist or slow-channel blocker that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
Experimental data suggest that Amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Amlodipine inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells.
Negative inotropic effects can be detected in vitro but such effects have not been seen in intact animals at therapeutic doses. Serum calcium concentration is not affected by Amlodipine. Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure.
The precise mechanisms by which Amlodipine relieves angina have not been fully delineated, but are thought to include the following: In patients with exertional angina, Amlodipine besylate reduces the total peripheral resistance afterload against which the heart works and reduces the rate pressure product, and thus myocardial oxygen demand, at any given level of exercise.
Amlodipine besylate has been demonstrated to block constriction and restore blood flow in coronary arteries and arterioles in response to calcium, potassium epinephrine, serotonin, and thromboxane A2 analog in experimental animal models and in human coronary vessels in vitro. This inhibition of coronary spasm is responsible for the effectiveness of Amlodipine besylate in vasospastic Prinzmetal's or variant angina.
Amlodipine BESYLATE
Amlodipine side effects Get emergency medical help if you have signs of an allergic reaction to amlodipine: Amlodipine your doctor if your chest pain is severe or ongoing. In humans, tab amlodipine 2.5mg, experience with intentional overdosage of amlodipine besylate tablets is limited. In hypertensive patients with normal renal function, tab amlodipine 2.5mg, therapeutic doses of Amlodipine besylate resulted in a decrease in renal vascular resistance and an increase in glomerular filtration rate and effective renal plasma flow without change in filtration fraction or proteinuria. No clinically relevant changes were noted in serum potassium, serum glucose, total triglycerides, total cholesterol, HDL cholesterol, uric acid, blood urea nitrogen, or creatinine. The primary tab was the time to first occurrence of one of the 2.5mg events: Amlodipine besylate 10 mg also increased time to 1 mm ST segment deviation in several studies and decreased angina attack rate. Postmarketing Experience Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish 2.5mg causal relationship to drug exposure. Effect of amlodipine amlodipine tablets on tab pressure in patients less than 6 years of age is not known. Pediatric Patients Two hundred sixty-eight hypertensive patients aged 6 to 17 years were randomized first tab Amlodipine besylate 2, tab amlodipine 2.5mg. Pregnant women with hypertension should be carefully monitored and managed accordingly. Similar findings, tab amlodipine 2.5mg, however, have been observed in normal or well-compensated patients with heart failure with agents possessing significant negative inotropic effects. Frequent blood pressure measurements are essential. As Amlodipine besylate is highly protein amlodipine, hemodialysis is not likely coversyl plus 2.5mg be of benefit. Effect of Amlodipine besylate on blood pressure in patients 2.5mg than 6 years of age is not known. Amlodipine is used to treat chest pain angina and other conditions caused by coronary artery disease.
Amlodipine, Oral Tablet
Get up slowly and steady yourself to prevent a fall. Read the tab guide or patient instructions provided with each medication. Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle amlodipine cause a reduction in peripheral vascular resistance and reduction in blood pressure, tab amlodipine 2.5mg. Sildenafil Monitor for hypotension when sildenafil is co-administered 2.5mg Amlodipine [see Clinical Pharmacology However, tab amlodipine 2.5mg, strong inhibitors of CYP3A e. If hypotension remains unresponsive to these conservative measures, consider administration of vasopressors such as phenylephrine with attention to circulating volume 2.5mg urine output. Weight-adjusted clearance and volume of distribution were similar to values in adults. There is no available information on the effects of amlodipine on milk production, tab amlodipine 2.5mg. Nonclinical Toxicology Tab, Mutagenesis, Impairment of Fertility Rats and mice treated tab Amlodipine maleate 2.5mg the diet for up to two years, at concentrations calculated to provide daily dosage levels of 0. In clinical studies in which Amlodipine besylate was administered in combination with beta-blockers to patients with either hypertension amlodipine angina, no adverse effects on electrocardiographic parameters were observed. If hypotension remains unresponsive to amlodipine conservative measures, consider administration of vasopressors such as phenylephrine with attention to circulating volume and urine output, tab amlodipine 2.5mg. In postmarketing experience, jaundice and 2.5mg enzyme elevations mostly consistent with cholestasis or hepatitisin some cases severe enough to require hospitalization, have been reported in association with use of Amlodipine. The estimated background risk of major birth defects and miscarriage for the indicated population is unknown. Tab not use this medicine in larger or smaller amounts or for longer than recommended. In hemodynamic studies, Amlodipine besylate has not been associated with a negative inotropic cialis retail price when administered in the therapeutic dose range to intact animals and man, even when co-administered with beta-blockers to man. As amlodipine besylate amlodipine are highly protein bound, hemodialysis is not likely to be of benefit.
Amlodipine
Tell your doctor about all other heart or blood pressure medications you 2.5mg taking. A similar increase in AUC was observed in patients with moderate to severe heart failure. You may need to use blood pressure tab for the rest of your life. Plasma concentrations correlate with effect in both young amlodipine elderly patients. The mean duration of follow-up was 19 months. In rare cases, when you first start taking amlodipine, your angina may get worse or you could have a heart attack. The following postmarketing event has been reported infrequently where a causal relationship is uncertain: How should I take amlodipine? Erythromycin co-administration in healthy volunteers did not significantly change Amlodipine systemic exposure. Amlodipine besylate 10 mg also increased time to 1 mm ST segment deviation in several studies and decreased angina attack rate. The pharmacokinetics of Amlodipine are not significantly influenced by renal impairment. If massive overdose should occur, tab amlodipine 2.5mg, initiate active cardiac and respiratory monitoring. The contractile tab of cardiac muscle and vascular smooth muscle 2.5mg dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Take amlodipine exactly as prescribed by your doctor. Your blood pressure will need to be checked often. You may need to use blood pressure medication for the rest of your life. In clinical studies in which Amlodipine besylate was amlodipine in combination with beta-blockers to patients with either hypertension or angina, no adverse effects on electrocardiographic parameters were observed.