Topamax 25mg plm
You should avoid drinking alcohol when taking Topamax. If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.
Your doctor will discuss use of contraceptives with you, as well as discussing whether Topamax is suitable for you. As with other anti-epileptic medicines, there is a risk of harm to the unborn child if Topamax is used during pregnancy. Make sure you are very clear about the risks and the benefits of using Topamax for epilepsy during pregnancy.
You should not take Topamax for migraine prevention if you are pregnant or you are able to become pregnant and you are not using effective contraception. Mothers who breast-feed while taking Topamax must tell the doctor as soon as possible if the baby experiences anything unusual. Dizziness, tiredness and vision problems may occur during treatment with Topamax. Do not drive or use any tools or machines without talking to your doctor first. Topamax contains lactose If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. Topamax and certain other medicines can affect each other. Sometimes the dose of some of your other medicines or Topamax will have to be adjusted.
Check with your doctor or pharmacist if you are not sure. Tell your doctor, or seek medical attention immediately if you have the following side effects: In some patients, hyperammonemia can be asymptomatic. Monitoring For Hyperammonemia Patients with inborn errors of metabolism or reduced hepatic mitochondrial activity may be at an increased risk for hyperammonemia with or without encephalopathy.
Although not studied, topiramate treatment or an interaction of concomitant topiramate and valproic acid treatment may exacerbate existing defects or unmask deficiencies in susceptible persons.
In patients who develop unexplained lethargy, vomiting or changes in mental status associated with any topiramate treatment, hyperammonemic encephalopathy should be considered and an ammonia level should be measured. Carbonic anhydrase inhibitors can promote stone formation by reducing urinary citrate excretion and by increasing urinary pH [see Metabolic Acidosis]. Increased fluid intake increases the urinary output, lowering the concentration of substances involved in stone formation.
Hydration is recommended to reduce new stone formation. Clinical management and assessment should include examination of blood ammonia levels. Metabolic Acidosis Warn patients about the potential significant risk for metabolic acidosis that may be asymptomatic and may be associated with adverse effects on kidneys e. Some patients with refractory epilepsy will need to avoid such activities altogether. Discuss the appropriate level of caution with patients, before patients with epilepsy engage in such activities.
Also inform patients that infants exposed to topiramate monotherapy in utero may be small for their gestational age [see Use in Specific Populations]. When appropriate, counsel pregnant women and women of childbearing potential about alternative therapeutic options. The registry is collecting information about the safety of antiepileptic drugs during pregnancy [see Use in Specific Populations].
Hyperammonemia And Encephalopathy Warn patients about the possible development of hyperammonemia with or without encephalopathy. Tell patients that they should not take a double dose in the event of a missed dose. Advise patients to contact their healthcare provider if they have missed more than one dose. The relevance of this finding to human carcinogenic risk is uncertain.
Mutagenesis Topiramate did not demonstrate genotoxic potential when tested in a battery of in vitro and in vivo assays. Topiramate was not mutagenic in the Ames test or the in vitro mouse lymphoma assay; it did not increase unscheduled DNA synthesis in rat hepatocytes in vitro; and it did not increase chromosomal aberrations in human lymphocytes in vitro or in rat bone marrow in vivo.
When multiple species of pregnant animals received topiramate at clinically relevant doses, structural malformations, including craniofacial defects, and reduced fetal weights occurred in offspring.
This registry is collecting information about the safety of antiepileptic drugs during pregnancy. To enroll, patients can call the toll-free number Human Data Data from pregnancy registries indicate an increased risk of oral clefts in infants exposed to topiramate during the first trimester of pregnancy. It was also higher than the background prevalence in United States 0. The UK Epilepsy and Pregnancy Register reported a prevalence of oral clefts among infants exposed to topiramate monotherapy 3.
The long term consequences of the SGA findings are not known. The effect of topiramate-induced metabolic acidosis has not been studied in pregnancy; however, metabolic acidosis in pregnancy due to other causes can cause decreased fetal growth, decreased fetal oxygenation , and fetal death, and may affect the fetus' ability to tolerate labor.
Animal Data Topiramate has demonstrated selective developmental toxicity, including teratogenicity, in multiple animal species at clinically relevant doses. The low dose is approximately 0. When female rats were treated during the latter part of gestation and throughout lactation 0.
The effects of this exposure on infants are unknown. Caution should be exercised when administered to a nursing woman.
Pediatric Use Adjunctive Treatment For Partial Onset Epilepsy In Pediatric Patients 1 To 24 months Safety and effectiveness in patients below the age of 2 years have not been established for the adjunctive therapy treatment of partial onset seizures, primary generalized tonic-clonic seizures, or seizures associated with Lennox-Gastaut syndrome.
In a single randomized, double-blind, placebo-controlled investigational trial, the efficacy, safety, and tolerability of topiramate oral liquid and sprinkle formulations as an adjunct to concurrent antiepileptic drug therapy in pediatric patients 1 to 24 months of age with refractory partial onset seizures were assessed.
Topamax 25 mg Tablets
If you are not sure if any of the 25mg applies to you, talk to your doctor or pharmacist before using Topamax. If at any time you have these thoughts, immediately contact your doctor. No age-related differences in effectiveness or adverse effects were evident. This increased frequency of abnormal plm was not dose-related, topamax 25mg plm. If you are pregnant or breast-feeding, topamax 25mg plm, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this plm. For the monotherapy epilepsy population, the incidence of somnolence was dose-related. Show this list to your doctor and pharmacist before topamax start a new medicine. For topamax migraine population, the incidences of both fatigue and somnolence were dose-related and more topamax in the titration phase. Epilepsy and many other illnesses for which AEDs are prescribed are themselves associated with morbidity and mortality and an increased risk of suicidal thoughts and behavior. Plm not studied, topiramate treatment or 25mg interaction of concomitant topiramate and valproic acid treatment may exacerbate existing defects or unmask deficiencies in susceptible 25mg.
What Is Topiramate 25 Mg?
TOPAMAX 25MG TABLETS
You should not take Topamax for migraine prevention if you are pregnant or you are able to become pregnant and you are not using effective contraception. Keep a plm of all the medicines you take. Other medicines you should discuss with your doctor or pharmacist topamax other anti-epileptic medicines, risperidone, lithium, hydrochlorothiazide, metformin, diltiazem, venlafaxine, flunarazine, St. Hydration is recommended to reduce plm stone formation. It was also higher than the background prevalence in United States 0. Mean change from baseline in certain CANTAB tests suggests that topiramate treatment may result in psychomotor slowing and decreased verbal fluency. In this rapid titration regimen, these dose-related adverse reactions began in the titration or in the maintenance phase, topamax 25mg plm, and in some patients these events began during titration and persisted into the maintenance phase. If you are losing too much weight price azithromycin tablets a child using this medicine is 25mg gaining enough weight, topamax 25mg plm, you should consult your doctor. Pediatric Use Adjunctive Treatment For Partial Onset Epilepsy In Pediatric Patients 1 To 24 months Safety and plm in patients below the age of 2 years have not been established for the adjunctive therapy treatment of partial 25mg seizures, primary generalized tonic-clonic seizures, or seizures associated with Lennox-Gastaut syndrome. Mutagenesis Topiramate did not demonstrate genotoxic 25mg when tested in a battery of in vitro and in vivo assays. Should suicidal thoughts and behavior emerge during treatment, the prescriber needs to consider whether the emergence of topamax symptoms in any given patient may be related to the illness being treated. Hemodialysis is an effective means of removing topiramate topamax the body.