If you have symptoms of these problems, you should go to the emergency room or call right away. Clinical monitoring Before starting treatment with clopidogrel, your doctor may do a genetic test to check your CYP2C19 genotype. The genetic test will help your doctor decide if you should take clopidogrel.
Some genotypes slow how clopidogrel is broken down. If you have this kind of genotype, this drug may not work for you. To make sure your medicine is working and is safe for you, your doctor will check the following: Are there any alternatives? There are several medications in this class and others to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives. Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date.
However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication.
The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Platelet aggregation and bleeding time gradually return to baseline values after treatment is discontinued, generally in about 5 days. Hepatically Impaired Patients After repeated doses of 75 mg Clopidogrel bisulfate per day for 10 days in patients with severe hepatic impairment, inhibition of ADP-induced platelet aggregation was similar to that observed in healthy subjects.
Gender In a small study comparing men and women, less inhibition of ADP-induced platelet aggregation was observed in women. Pharmacokinetics Clopidogrel is a prodrug and is metabolized to a pharmacologically active metabolite and inactive metabolites.
Absorption After single and repeated oral doses of 75 mg per day, Clopidogrel is rapidly absorbed. Effect of Food Clopidogrel bisulfate can be administered with or without food. Similar results were observed when a Clopidogrel bisulfate mg loading dose was administered with a high-fat breakfast. Metabolism Clopidogrel is extensively metabolized by two main metabolic pathways: Cytochromes first oxidize Clopidogrel to a 2-oxo-Clopidogrel intermediate metabolite.
Subsequent metabolism of the 2-oxo-Clopidogrel intermediate metabolite results in formation of the active metabolite, a thiol derivative of Clopidogrel. The active thiol metabolite binds rapidly and irreversibly to platelet receptors, thus inhibiting platelet aggregation for the lifespan of the platelet. The Cmax of the active metabolite is twice as high following a single mg Clopidogrel loading dose as it is after four days of 75 mg maintenance dose.
Cmax occurs approximately 30 to 60 minutes after dosing. In the 75 to mg dose range, the pharmacokinetics of the active metabolite deviates from dose proportionality: After a single, oral dose of 75 mg, Clopidogrel has a half-life of approximately 6 hours.
The half-life of the active metabolite is about 30 minutes. Concomitant use of certain inhibitors of this enzyme results in reduced plasma concentrations of the active metabolite of Clopidogrel and a reduction in platelet inhibition. Proton Pump Inhibitors PPI The effect of proton pump inhibitors PPI on the systemic exposure to the Clopidogrel active metabolite following multiple doses of Clopidogrel bisulfate 75 mg evaluated in dedicated drug interaction studies is presented in Figure 1.
Pharmacodynamic and pharmacokinetic parameters measured in these studies showed that the interaction was highest with omeprazole and least with dexlansoprazole. Effect of Clopidogrel bisulfate on other drugs In vitro studies have shown that the glucuronide metabolite of Clopidogrel is a strong inhibitor of CYP2C8. Pharmacogenomics CYP2C19 is involved in the formation of both the active metabolite and the 2-oxo-Clopidogrel intermediate metabolite. Clopidogrel active metabolite pharmacokinetics and antiplatelet effects, as measured by ex vivo platelet aggregation assays, differ according to CYP2C19 genotype.
Tests are available to identify patients who are CYP2C19 poor metabolizers. A crossover study in 40 healthy subjects, 10 each in the four CYP2C19 metabolizer groups, evaluated pharmacokinetic and antiplatelet responses using mg followed by 75 mg per day and mg followed by mg per day, each for a total of 5 days. Decreased active metabolite exposure and diminished inhibition of platelet aggregation were observed in the poor metabolizers as compared to the other groups.
Taking other medicines Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. Some other medicines may influence the use of Clopidogrel Tablets or vice versa. Taking Clopidogrel Tablets with food and drink Clopidogrel Tablets may be taken with or without food.
Pregnancy and breast-feeding It is preferable not to take this product during pregnancy. If you are pregnant or suspect that you are pregnant, you should tell your doctor or your pharmacist before taking Clopidogrel Tablets. If you become pregnant while taking Clopidogrel Tablets, consult your doctor immediately as it is recommended not to take clopidogrel while you are pregnant.
You should not breast-feed while taking this medicine. If you are breast-feeding or planning to breast-feed, talk to your doctor before taking this medicine. Ask your doctor or pharamcist for advice before taking any medicine. Driving and using machines Clopidogrel Tablets are unlikely to affect your ability to drive or to use machines. Important information about some of the ingredients in Clopidogrel Tablets This medicine contains hydrogenated castor oil, which may cause stomach upsets and diarrhoea.
You should check with your doctor or pharmacist if you are not sure. The usual dose is one 75mg tablet of Clopidogrel per day to be taken orally with or without food, and at the same time each day. You should take Clopidogrel Tablets for as long as your doctor continues to prescribe it.
If you take more Clopidogrel Tablets than you should Contact your doctor or nearest hospital emergency department because of the increased risk of bleeding. If you forget to take Clopidogrel Tablets If you forget to take a dose of Clopidogrel Tablets, but remember within 12 hours of your usual time, take your tablet straight away and then take your next tablet at the usual time.
If you forget for more than 12 hours, simply take the next single dose at the usual time. Do not take a double dose to make up for the forgotten individual doses. If you stop taking Clopidogrel Tablets Do not stop the treatment unless your doctor tells you so. Contact your doctor or pharmacist before stopping.
If you have any further questions on the use of this product, ask your doctor or pharamcist. The frequency of possible side effects listed below is defined using the following convention: These may be the signs of an allergic reaction. The most common side effect reported with Clopidogrel Tablets is bleeding.
Bleeding may occur as bleeding in the stomach or bowels, bruising, haematoma unusual bleeding or bruising under the skin , nose bleed, blood in the urine. In a small number of cases, bleeding in the eye, inside the head, the lung or the joints has also been reported. If you experience prolonged bleeding when taking Clopidogrel Tablets If you cut or injure yourself, it may take longer than usual for bleeding to stop.
75mg are, however, no adequate and well-controlled studies in pregnant women, clopidogrel tablets 75mg. Cmax occurs approximately 30 to 60 minutes after dosing. The frequency of possible side effects listed below is defined using the following convention: You have a condition of hardening of the arteries also known as tabletand You have previously experienced a tablet attack, stroke or have a tablet known as peripheral arterial disease. If any of the side effects clopidogrel serious, or if you notice any side effects not listed 75mg this clopidogrel, please tell your doctor or pharmacist, clopidogrel tablets 75mg. The active thiol metabolite binds rapidly and irreversibly to platelet receptors, thus inhibiting platelet aggregation for the lifespan of the platelet. What should I 75mg while taking clopidogrel Plavix? Avoid activities that may increase your risk of bleeding or injury. If Plavix must be temporarily discontinued clopidogrel.
© Copyright 2017 Clopidogrel tablets 75mg. wordpressangulartest.azurewebsites.net.