Aldactone a 50mg
How to take Aldactone Tell your doctor or pharmacist if you are taking, have recently 4. Possible side effects taken or might take any other medicines, including medicines 5.
How to store Aldactone obtained without prescription. Your doctor may wish to alter your 6. Caution is advised when driving or operating machinery until the response to initial treatment has been determined.
Laboratory Tests Periodic determination of serum electrolytes to detect possible electrolyte imbalance should be done at appropriate intervals, particularly in the elderly and those with significant renal or hepatic impairments. There was also a statistically significant, but not dose-related, increase in benign uterine endometrial stromal polyps in females.
In two-year studies in the rat, oral administration of potassium canrenoate was associated with myelocytic leukemia and hepatic, thyroid, testicular, and mammary tumors. In the presence of metabolic activation, ALDACTONE has been reported to be negative in some mammalian mutagenicity tests in vitro and inconclusive but slightly positive for mutagenicity in other mammalian tests in vitro.
In the presence of metabolic activation, potassium canrenoate has been reported to test positive for mutagenicity in some mammalian tests in vitro, inconclusive in others, and negative in still others. These effects were associated with retarded ovarian follicle development and a reduction in circulating estrogen levels, which would be expected to impair mating, fertility, and fecundity.
Spironolactone should be used with caution in patients with impaired hepatic function because minor alterations of fluid and electrolyte balance may precipitate hepatic coma. Precautions General All patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance, e. Serum and urine electrolyte determinations are particularly important when the patient is vomiting excessively or receiving parenteral fluids. Warning signs or symptoms of fluid and electrolyte imbalance, irrespective of cause, include dryness of the mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia and gastrointestinal disturbances such as nausea and vomiting.
Hyperkalemia may occur in patients with impaired renal function or excessive potassium intake and can cause cardiac irregularities, which may be fatal. Consequently, no potassium supplement should ordinarily be given with Spironolactone. If hyperkalemia is suspected warning signs include paresthesia, muscle weakness, fatigue, flaccid paralysis of the extremities, bradycardia and shock , an electrocardiogram ECG should be obtained.
However, it is important to monitor serum potassium levels because mild hyperkalemia may not be associated with ECG changes. If hyperkalemia is present, Spironolactone should be discontinued immediately.
With severe hyperkalemia, the clinical situation dictates the procedures to be employed. These are temporary measures to be repeated as required. Cationic exchange resins such as sodium polystyrene sulfonate may be orally or rectally administered.
Persistent hyperkalemia may require dialysis. Reversible hyperchloremic metabolic acidosis, usually in association with hyperkalemia, has been reported to occur in some patients with decompensated hepatic cirrhosis, even in the presence of normal renal function. Dilutional hyponatremia, manifested by dryness of the mouth, thirst, lethargy and drowsiness, and confirmed by a low serum sodium level, may be caused or aggravated, especially when Spironolactone is administered in combination with other diuretics, and dilutional hyponatremia may occur in edematous patients in hot weather; appropriate therapy is water restriction rather than administration of sodium, except in rare instances when the hyponatremia is life threatening.
Spironolactone therapy may cause a transient elevation of BUN, especially in patients with preexisting renal impairment. You may report side effects to Health Canada at Click here to view a more detailed list of Aldactone side effects. If you miss a dose of Aldactone Spironolactone 50mg, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
See also Precautions section. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Some products that may interact with Aldactone Spironolactone 50mg include: Some products have ingredients that could raise your blood pressure or worsen your swelling. Aldactone Spironolactone 50mg may interfere with certain laboratory tests including digoxin or cortisol levels , possibly causing false test results. Caution is advised when driving or operating machinery until the response to initial treatment has been determined.
Information for Patients Patients who receive Spironolactone should be advised to avoid potassium supplements and foods containing high levels of potassium, including salt substitutes.
Laboratory Tests Periodic determination of serum electrolytes to detect possible electrolyte imbalance should be done at appropriate intervals, particularly in the elderly and those with significant renal or hepatic impairments.
Alcohol, Barbiturates or Narcotics Potentiation of orthostatic hypotension may occur. Therefore, caution should be exercised in the management of patients subjected to regional or general anesthesia while they are being treated with Spironolactone. Skeletal Muscle Relaxants, Nondepolarizing e. Lithium Lithium generally should not be given with diuretics. Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity.
Therefore, when Spironolactone and NSAIDs are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained. Digoxin Spironolactone has been shown to increase the half-life of digoxin. This may result in increased serum digoxin levels and subsequent digitalis toxicity. It may be necessary to reduce the maintenance and digitalization doses when Spironolactone is administered, and the patient should be carefully monitored to avoid over or under digitalization.
Cholestyramine Hyperkalemic metabolic acidosis has been reported in patients given Spironolactone concurrently with cholestyramine. Neither the extent nor the potential clinical significance of its interference which may be assay-specific has been fully established. Carcinogenesis, Mutagenesis, Impairment of Fertility Orally administered Spironolactone has been shown to be a tumorigen in dietary administration studies performed in rats, with its proliferative effects manifested on endocrine organs and the liver.
There was also a statistically significant, but not dose related, increase in benign uterine endometrial stromal polyps in females. Some research suggests that spironolactone has the potential to feminize male fetuses during early pregnancy and cause endocrine problems in late pregnancy by inhibiting the activity of male hormones androgens.
In general, diuretics such as spironolactone aren't recommended for pregnant women. Unless the drug is absolutely necessary, it's not recommended for women who are breastfeeding because canrenone, a byproduct of spironolactone, is excreted in breast milk.
Brand Name Aldactone
Spironolactone has not been shown to be anti-inflammatory, nor to affect the basic pathological process. Metabolites can be divided into two main categories: On a body surface area basis, aldactone a 50mg, this dose in the mouse is substantially below the maximum recommended human aldactone and, in the rabbit, approximates the maximum recommended human dose. Talk to your doctor or pharmacist before taking Aldactone if: Aldactone, it is important to monitor aldactone potassium levels because mild hyperkalemia may not be associated with ECG changes. Warning signs or symptoms of fluid and electrolyte imbalance, irrespective of cause, include dryness of the mouth, thirst, aldactone a 50mg, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia and gastrointestinal disturbances such as nausea 50mg vomiting, aldactone a 50mg. These subgroup analyses must be interpreted cautiously. Induce vomiting or evacuate the stomach by lavage, aldactone a 50mg. Digoxin Spironolactone has been shown to increase the half-life 50mg digoxin. Consider the developmental 50mg health benefits of breastfeeding along with the 50mg clinical need for spironolactone and any potential adverse effects on the breastfed child from spironolactone or from the underlying maternal condition, aldactone a 50mg. It is also effective in most cases of essential hypertensiondespite the fact that aldosterone secretion may be within normal limits in benign essential hypertension. Spironolactone should be used with caution in patients 50mg impaired hepatic function because minor alterations of fluid and electrolyte balance may precipitate hepatic coma. These are temporary measures to be repeated as required. You may take the liquid form of Aldactone Spironolactone 50mg with or without food, but it is important to choose one way and take phenergan 10mg drowsy aldactone same way with every dose.
Spironolactone
Somnolence and dizziness have been reported to occur in some patients. Make aldactone laboratory personnel and all your doctors know you use Aldactone Aldactone 50mg. There is no specific antidote. Hyperkalemia in Patients with Severe Heart Failure for advice on monitoring serum potassium and serum creatinine. Laboratory Tests Periodic determination of serum electrolytes to detect possible electrolyte imbalance should be done at appropriate intervals, particularly in the elderly and those with significant renal or hepatic impairments. This document does not contain all possible drug interactions. 50mg Canada - Call your doctor for medical advice about side effects. Pregnant women with cirrhosis of the liver should be carefully monitored and managed accordingly. Serum and urine electrolyte determinations are particularly important when the patient is vomiting excessively or receiving parenteral fluids. In the presence of metabolic activation, potassium canrenoate has been 50mg to test positive for mutagenicity in some mammalian tests in vitro, inconclusive in others, and negative in still others. Inactive ingredients include calcium sulfate, corn starch, flavor, hypromellose, iron oxide, magnesium stearate, polyethylene glycol, povidone, aldactone a 50mg, and titanium dioxide. In the presence of metabolic activation, aldactone a 50mg, Aldactone has been reported to be negative in some mammalian mutagenicity tests in vitro and inconclusive but slightly positive for mutagenicity in other mammalian tests in vitro. What you need to know before you take Aldactone Other medicines and Aldactone 3.
What Is The Use Of Aldactone Tablet?
Spironolactone
Essential hypertension high blood pressure with an unknown cause Hypokalemia potassium deficiency Edema fluid retention from various conditions, including congestive heart failurekidney disease, and cirrhosis liver scarring Severe heart failure Spironolactone is a potassium-sparing diuretic. There is no specific antidote. Aldactone Spironolactone 50mg is alprazolam price walgreens used aldactone treat low potassium levels and conditions in which the body is making too much of a natural chemical aldosterone. On a body surface area basis, this dose in the mouse is substantially below the maximum recommended human dose and, aldactone a 50mg, in the rabbit, approximates the maximum recommended human dose. The antiandrogenic effects can result in apparent estrogenic side effects in humans, such as gynecomastia. 50mg that your doctor has prescribed Aldactone Spironolactone 50mg because he or she has judged that the benefit to you is greater than 50mg risk of side effects. Symptoms of hyperkalaemia may manifest as paraesthesia, weakness, flaccid paralysis or muscle spasm and may be difficult to distinguish clinically from hypokalaemia. Spironolactone acts both as a diuretic and as an antihypertensive drug by this mechanism. After the diagnosis of 50mg has been established by more definitive testing procedures, Aldactone may be administered at doses of mg to mg daily in preparation for surgery. There are no adequate and well controlled studies with Spironolactone in pregnant women, aldactone a 50mg. In the presence of metabolic activation, Spironolactone has been aldactone to be negative in aldactone mammalian mutagenicity tests in vitro and inconclusive but slightly positive for mutagenicity in other mammalian tests in vitro. Precautions General All patients receiving diuretic therapy should be observed for evidence of fluid or electrolyte imbalance, e. With severe hyperkalemia, the clinical situation dictates the procedures to be employed. These are temporary measures to be repeated as required. It is critical to monitor and manage serum potassium in patients with severe heart failure receiving spironolactone.